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KMID : 0861220030050020171
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Journal of the Korean Society Clinical Neurophysiology
2003 Volume.5 No. 2 p.171 ~ p.176
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Effect of Ketogenic Diet on the Nitric Oxide of Pilocarpine-induced Status Epilepticus
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Kim Tae-Woo
Kim Jae-Moon
Park Hee-Dong
Jung Ki-Young
Kim Dong-Wook
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Abstract
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Background and Objectives :Despite of enormous clinical and laboratory researches focused on the useful markers in status epilepticus(SE), clinically applicable methods are not yet available. Although ketogenic diet (KD) is an old method of treating epilepsies, its outstanding antiepileptic effect in some epileptic patients needs re-evaluation of this methods. This study was performed to evaluate the effect of KD on the change of nitric oxide(NO) during the SE.
Methods:After the determination of critical EEG stages in the pilocarpine-induced SE model, serum NO levels were measured with Griess reaction. Open cardiac puncture was done immediately after the four different EEG stages of SE in the KD rats and regular diet (RD) rats. Cessation of SE was done with the 10~20 mg/Kg of diazepam i.p. injection in each stages of SE in KD and RD rats.
Results:Pilocarpine-induced SE showed reliable EEG and behavioral patterns in all rats. Also, KD did not affect the SE induced by pilocarpine in terms of the SE induction time and SE severity. Serum NO was consistently higher in KD rats than RD rats in all SE stages.
Conclusions:KD significantly increases NO during the pilocarpine-induced SE. These finding might contribute the neuroprotective effect of KD in the SE.
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KEYWORD
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Status epilepticus, Ketogenic diet, Nitric oxide
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